Immune thrombocytopenia (ITP) is a type of thrombocytopenic purpura defined as isolated low platelet count (thrombocytopenia) with normal bone marrow and. Idiopathic thrombocytopenic purpura (ITP) or immune thrombocytopenic purpura is a disease .. Purwanto I. Purpura trombositopenia idiopatik. In: Sudoyo AW. Idiopathic thrombocytopenic purpura (ITP) or immune thrombocytopenic purpura is a disease Purwanto I. Purpura trombositopenia idiopatik.
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People with the disease have too few platelets in the blood. Chronic immune thrombocytopenia persists longer than six months with a specific cause being unknown. The trombositlpenia of ITP also requires a medical history anamnesisphysical examination, platelet count, and examination of a peripheral blood smear.
Persons with ITP who are 70 years or older are at increased risk for spontaneous bleeding and treatment-related adverse events. The latter examination in ITP shows low numbers of normal-sized platelets, occasionally also giant platelets, while erythrocytes and leukocytes have a normal morphology.
The clinical signs of ITP are purpura, ecchymosis, petechiae and gastrointestinal tract bleeding, gingival bleeding, epistaxis, and urinary tract bleeding. Diabetes mellitus type 1 Hashimoto’s thyroiditis Multiple sclerosis Coeliac disease Giant-cell arteritis Postorgasmic illness syndrome Reactive arthritis. The treatment begins with IV steroids methylprednisolone or prednisoneTdombositopenia or their combination and sometimes platelet infusions in order to raise trombositopwnia count quickly.
Allergic contact dermatitis Mantoux test.
Idiopathic thrombocytopenic purpura
Hematol Oncol Clin North Am ; Chronic idiopathic thrombocytopenic purpura: Older patients have more severe and rare bleeding manifestations, such as GI bleeding and possibly intracranial hemorrhage secondary to co-morbidities such as hypertension. Dapsone also called diphenylsulfone, DDS, or avlosulfon is an anti-infective sulfone drug. Medicine called danazol Danocrine taken by mouth Infusions of high-dose gamma globulin an immune factor Drugs that suppress the immune system Anti-RhD therapy rrombositopenia people with certain blood types Drugs that stimulate the bone marrow to make more platelets People with ITP should not take aspirin, ibuprofen, or warfarin, because these drugs interfere with platelet function or blood clotting, and bleeding may occur.
Thrombopoietin receptor agonists are pharmaceutical agents that stimulate platelet production in the bone marrow. Hematol Oncol Clin Nortn Am ; It is recommended that neonates be followed with serial platelet counts for the first few adallah after birth. This page was last edited on 27 Septemberat Conclusion The initial treatment of ITP includes: With rare exceptions, axalah is usually no need to treat based on platelet counts.
It causes a characteristic purpuric rash and an increased tendency to bleed. Blood tests will be done to check your tromhositopenia count. Support Center Support Center.
A bone marrow aspiration or biopsy may also be done. Current guidelines recommend treatment only in cases of significant bleeding. Petechia of the lower leg in a person with platelets of 3 due to ITP.
Idiopathic thrombocytopenic purpura
Another option, suitable for Rh-positive patients with functional spleens is intravenous administration of Rho D immune globulin [Human; Anti-D].
The procedure is potentially risky in ITP cases due to the increased possibility of significant bleeding during surgery. In a fifth, the platelet count normalized completely; this response rate is similar to that found in treatment with rituximab, which is more expensive and less safe. N Engl J Med ; Chronic idiopathic thrombocytopenic purpura. Retrieved October 16, Fetal blood analysis to determine the ppurpura count is not generally performed as ITP-induced thrombocytopenia in the fetus is generally less severe than NAIT.
The coating of platelets with IgG renders them susceptible to opsonization and phagocytosis by splenic macrophagesas well by Kupffer cells in the liver. Southern Med J ; Author teombositopenia Copyright and License information Disclaimer. In a study conducted in Great Britainit was noted that ITP causes an approximately 60 percent higher rate of mortality compared to gender- and age-matched subjects without ITP.
Extraoral examination revealed petechial spots over the neck on right side [ Figure 1 ], petechial spots over the forearms, and petechial spots over the right arm [ Figure 2 ]. Abstract Idiopathic thrombocytopenic purpura ITP is defined as a hematologic disorder, characterized by isolated thrombocytopenia without a clinically apparent cause. The initial treatment of ITP includes: In children, the disease affects boys and girls equally.
Semple JW, Freedman J. On the 2 nd day after the patient reported, there was increased bleeding, hematoma and gingival enlargement in lower anterior region [ Figure 4 ], and on the 4 th day, hematoma formation was seen in lower anterior region lingually [ Figure idlopatik ].
This is because the underlying autoimmune mechanism that is destroying the patient’s platelets will also destroy donor platelets, and so platelet transfusions are not considered a long-term treatment option.
Some children may need treatment. Diagnosis and treatment of idiopathic thrombocytopenic purpura: Many older recommendations suggested a certain platelet count threshold usually somewhere below The incidence of ITP is estimated at 50— new cases per million per year, with children accounting for half of that amount. Foreign Hemolytic disease of the newborn. The patient was followed-up for 2 years and there was no re-occurence reported.