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;(21)– [PubMed]; Constantopoulos A, Karpathios T, Nicolaidou P, Maounis F, Matsaniotis N. Lazy-leukocyte syndrome. A case report . The lazy leukocyte syndrome was first described by Miller et al. in in two children with recurrent infection. They had normal humoral and cellular immunity . – LAZY LEUKOCYTE SYNDROME. LAZY LEUKOCYTE SYNDROME. Clinical Synopsis Toggle Dropdown. Inheritance. -? Autosomal dominant new.

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Bone marrow studies showed normal numbers of mature, morphologically normal neutrophils. Please consider making a donation now and again in the future.

A characteristic abnormality of actin distribution in neutrophils was demonstrated. Both random mobility and chemotactic function were defective. Unfortunately, it is not free to produce. Mobilization of leukocytes after exercise was defective.

lazy leukocyte syndrome

We need long-term secure funding to provide you the information that you need at your fingertips. A severe neutropenia was found.


Syndrme of chemotaxis and random mobility. Leukocyte phagocytosis and bactericidal activity were normal. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions. A bonus to all MIMmatch users is the option to sign up for updates on new gene-phenotype relationships.

Lazy leukocyte syndrome | definition of lazy leukocyte syndrome by Medical dictionary

Looking For More References? We are determined to keep this website freely accessible. None is familial and no parental consanguinity is synvrome.

Miller knew of 4 other cases. Relative to the genetics and the possibility that these cases represent new dominant mutations, parental age data would be of interest. A poor neutrophil response was obtained upon stimulation with both epinephrine and endotoxin, as well as upon induced inflammation by the Rebuck skin window technique.

Lazy leukocyte syndrome.

Autosomal dominant new mutations. OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine.


Clinical Synopsis Toggle Dropdown. The same abnormality probably leads to impaired deformability of neutrophils so that release of newly formed neutrophils from the bone marrow is reduced.

The year-old proposita had neutropenia and an illness suggestive of persistent Epstein-Barr virus infection. Skin window mobilization test and chemotaxis were normal. Single cases were reported by Costanopoulos et al. The syndrome is distinguished from neutrophil chemotactic deficiencies by the coexistence of defective random motility and peripheral blood neutropenia with normal bone marrow granulocyte reserve.

A new disorder of neutrophil function. Transient ‘lazy-leukocyte’ syndrome during infancy. Expert curators review the literature and organize it to facilitate your work.